Treatment of relapsing thrombotic thrombocytopenic purpura with cyclophosphamide pulse therapy
نویسندگان
چکیده
منابع مشابه
Frequently relapsing thrombotic thrombocytopenic purpura treated with cytotoxic immunosuppressive therapy.
BACKGROUND AND OBJECTIVES Treatment of thrombotic thrombocytopenic purpura (TTP) with plasma exchange has reduced mortality rates from 90% in untreated cases to less than 20%. Despite plasma exchange, relapses may occur in as many as 40% of cases. Multiple relapses occur in a minority but pose a significant therapeutic challenge. Recent evidence supports the presence of an autoantibody which in...
متن کاملThrombotic Thrombocytopenic Purpura: Diagnosis and Treatment
Thrombotic Thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathic disease, associated with thrombocytopenia and hemolytic anemia. It is caused by an enzymatic dysfunction responsible in cleavage of blood clotting factors. In this study we have tried to review the available approaches in diagnoses of the disease as well as treatment strategies. Based on the what the current review ...
متن کاملPulse cyclophosphamide therapy for refractory autoimmune thrombocytopenic purpura.
Autoimmune thrombocytopenic purpura (AITP) is generally a chronic disorder in affected adults. Twenty-five percent of these patients will become refractory to routine therapy (corticosteroids and splenectomy), as well as most other available agents. Intravenous pulse cyclophosphamide therapy was used to treat 20 patients with severe refractory AITP who had previously failed to achieve a sustain...
متن کاملSplenectomy in patients with refractory or relapsing thrombotic thrombocytopenic purpura.
Haematologica vol. 85(4):April 2000 cation. In contrast, a few cases have been reported of HPS as an early and prominent manifestation of an underlying cell lymphoma.4,5 Differentiation from other causes of HPS is difficult and lack of histologic proof of malignancy in the initial stage often delays definitive diagnosis and treatment. Demonstration of clonal TCR gene rearrangements has been use...
متن کاملThrombotic thrombocytopenic purpura associated with ticlopidine therapy.
A patient who developed thrombotic microangiopathy while on ticlopidine therapy is reported. Thrombotic microangiopathy resolved with discontinuation of the drug and treatment with plasma exchange and has not recurred during 10 months of follow-up. The emerging data on the risk of developing thrombotic microangiopathy while on Ticlopidine and the possible mechanisms underlying this association ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 1998
ISSN: 1460-2385
DOI: 10.1093/ndt/13.5.1320